Apr
I drank an Arizona with caffeine in it, a 5 hour energy, a coffee, and chewed energy gum…in all it was around 8-10,000mg of caffeine, and I was completely normal. Nothing happens with caffeine, I sleep fine, I don't get hyper. The same thing with medicine! Advil and Ibuprofen don't help me ever and I take up to 5. The only time medicine really helps me is when it's directly injected or inhaled, like laughing gas and stuff they put through IV's. Just wondering what your views are, if the effects just aren't noticeable or what:). Thanks
Answer:
There’s a lot of variation between people with respect to drug response. Part of this variation is caused by different metabolic clearance rates of the drug. Drugs are chemically oxidized by enzymes in the liver, which makes them more water soluble, which allows you to pee them out. If you couldn't do this, drugs would stay in your body for a very long time, if not forever.
Caffeine is called a “stimulant” but in reality it only blocks your brain from receiving the signal that you are tired. It can not make you more energetic than normal, and people who claim it does are experiencing the placebo effect because popular culture believes that this is what caffeine does.
Caffeine is also metabolized in the liver by the enzyme: cytochrome P450 1A2 (or CYP1A2). Some people are slow metabolizers while others are moderate and some are fast. This depends on what gene you’ve for this enzyme. It sounds like you might be a CYP1A2 fast metabolizer, congratulations! This will make you less sensitive to many medications. Check out the CYP1A2 substrates in the following link. Also, if you regularly consume caffeine, you will become tolerant to its effects.
Advil and Ibuprofen are the same thing (advil is a brand). This drug is metabolized by CYP2C9. There are also fast and slow versions of this gene/enzyme. There might be something similar going on with your reaction to ibuprofen. That’s, you might be metabolizing it to the inactive form before it gets a chance to do its job. But, if you’re taking this medication for something that won't be helped by ibuprofen (a common mistake) then you won't see an effect.
Over the counter medications are often ineffective because of interpersonal variation in metabolism. But, these drugs are usually very safe, and it is not required to determine your unique personalized dose (but medicine is moving this direction). Laughing gas and IV drugs that are used in hospitals are a different story. They have the ability to be very perilous and they require special work by the doctors to determine your particular dose. Laughing gas and other anesthetics are dosed and monitored with extreme precision by anesthesiologists, which is why you recognize the effect.
http://www.pharmacytimes.com/issues/arti…
http://en.wikipedia.org/wiki/Caffeine#To…
Answer:
Hi
It can happen that even if a person is having a reaction to a substance it can be 'masked' by other factors.
Exclusion diets can reveal the true extent of a reaction.
Answer:
I'm the exact same. Caffeine doesn't really affect me.